Search results for " octreotide"
showing 4 items of 4 documents
Subcutaneous octreotide versus oral loperamide in the treatment of diarrhea following chemotherapy
1993
Forty patients with chemotherapy-related diarrhea were randomized to receive (i) octreotide 0.5 mg three times per day s.c. or (ii) loperamide 4 mg three times per day p.o. until complete remission of diarrhea was achieved. In the octreotide group 80% of patients showed complete resolution of loose bowel movements within 4 days of therapy, while in the loperamide group this goal was obtained in only 30% of cases (p < 0.001). If after 4 days no benefit was seen, patients were considered to have failed antidiarrheal therapy. Failure was recorded in only one case (5%) treated with s.c. octreotide and in five patients (25%) who received loperamide. The mean duration of antidiarrheal therapy nec…
Nonconventional Doses of Somatostatin Analogs in Patients With Progressing Well-Differentiated Neuroendocrine Tumor
2020
Abstract Purpose To evaluate the antiproliferative activity and safety of nonconventional high doses of somatostatin analogs (HD-SSA) in patients with well-differentiated gastroenteropancreatic (GEP) neuroendocrine tumors (NET) with radiological disease progression according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria on a previous treatment. Methods A retrospective analysis of prospectively maintained databases from 13 Italian NET-dedicated centers was performed. Main inclusion criteria were: well-differentiated G1 or G2 GEP-NET, progressive disease on a previous treatment, and subsequent treatment with HD-SSA (either by increased administered dose [dose intensity] or…
Modificazioni dell’emodinamica splancnica dopo somministrazione endovenosa di terlipressina in associazione ad infusione di octreotide nel suino.
2014
L’obiettivo di questo studio è valutare gli effetti sull’emodinamica splancnica dopo la somministrazione di terlipressina in associazione all’infusione endovenosa di octeotride. La terlipressina trova impiego clinico nella terapia selettiva delle emorragie da varici esofagee, principale complicanza dell’ipertensione portale, senza provocare alterazioni della dinamica emocoagulativa. L’uso dell’octreotide è ben conosciuto come valida terapia per emorragia delle varici in pazienti cirrotici attraverso la riduzione della pressione portale e il flusso sanguigno portocollaterale. Lo scopo del presente studio è valutare gli effetti dell’associazione farmacologica di terlipressina e octreotide nel…